For instance, supplementation of MDM culture media with M-CSF induces expression of phosphorylated SAMHD1 that does not have anti-viral activity [120,121], while addition of GM-CSF induces expression of G1/S-specific cyclin D2 and dephosphorylation of SAMHD1, thus limiting HIV infection [122]. The gene discussed is SAMHD1; the disease is HIV infectious disease.