The relationship between high pathological grading and EMT was already described for other EMT-related signaling factors, like Secreted Protein Acidic and Rich in Cysteine (SPARC) and TEA domain TF 4 (TEAD4), in HNC [48,49] and might be a consequence of increasing de-differentiation of the cancer cells as a consequence of EMT [44]. This evidence concerns the gene SPARC and cancer.