Numerous studies demonstrated that ginseng and/or ginsenosides suppressed obesity and adipocyte inflammation by regulating several pathways, such as matrix metalloproteinases (MMP)-2 and MMP-9 [40], AMPK signaling [41], and/or PPAR-γ signal pathways [42,43]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.