5XFAD mouse is a transgenic model of AD, which overexpresses familial AD mutations, namely K670N/M671L (Swedish), I716V (Florida), and V717I (London) mutations in APP and M146L/L286V mutations in PS1, and shows Aβ deposition, phosphorylated tau deposition, neuronal loss, axonal degeneration, and memory deficits [36,37,38,39]. Here, MAPT is linked to Alzheimer disease.