The high levels of PADI1 observed here in the SARS-CoV-2 skin biopsies may possibly contribute to some of the cutaneous manifestations related to COVID-19, which include an erythematous rash, urticarial, chickenpox-like vesicles, acral lesions (“COVID toes”) and livedoid lesions [11,133]. Here, PADI1 is linked to chickenpox.