In the adenocarcinoma lung cells, PADI4 mRNA levels stayed similar in SARS-CoV-2-infected compared to mock infected cells, possibly indicating lower viral defence mechanisms via PAD4, while PADI2 was elevated, and may be the dominating PADI isoform acting as part of its anti-viral and pathogenic immune related functions in this cell line. Here, PADI2 is linked to adenocarcinoma.