The photoreceptor preservative effect related to upregulation of endogenous CNTF after mechanical or light-induced damage is well-reported in literature [14,29,30], and multiple teams working on viral-mediated gene therapies or sustained release delivery systems have demonstrated the protective effects of CNTF in different animal models of retinal degeneration [31,32,33,34,35,36]. This evidence concerns the gene CNTF and retinal degeneration.