We were restricted in expanding on our mediation models and to model combined serial and parallel mediation and moderation processes by including additional biological variables (e.g., estrogen status) to test our hypothesis based on a-priori variables (e.g., obesity, insulin, and androgen status) due to the PROCESS macro limitations, which are not uncommon in studies of this type [135]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.