In 2012, Barbui et al. proposed a 3-tiered score (with the addition of an intermediate-risk group) called the “International Prognostic Score of Thrombosis for Essential Thrombocythemia” (IPSET-thrombosis model), which accounted for the presence of cardiovascular risk factors and JAK2 V617F mutation [34]. Here, JAK2 is linked to Venous thrombosis.