The first, performing WGS or WES on 1120 pediatric cancer patients (39 HGOS), identified TP53, APC, breast related cancer antigen 2 (BRCA2), neurofibromin 1 (NF1), PMS1 homolog 2, mismatch repair system component (PMS2), RB transcriptional corepressor 1 (RB1) and RUNX family transcription factor 1 (RUNX1) to be affected by mutations in more than three cases [35]. Here, RB1 is linked to cancer.