HAS3 and cardiomyopathy: In another large study including pediatric patients with bone tumors, using a cardiovascular SNP array to profile common SNPs in 2100 genes considered relevant to de novo cardiovascular disease, the AA genotype of rs2232228 in the hyaluronan synthase 3 (HAS3) gene conferred an increased risk for cardiomyopathy compared to the AA genotype [118].