The increased activity and expression of CRL4-DCAF1 in Merlin-deficient meningioma, compared to Merlin-positive control cells, could explain why they have increased sensitivity to MLN3651, and therefore, the expression of both CRL4-DCAF1 and KSR1 should be explored further in Merlin-positive meningioma. The gene discussed is NF2; the disease is meningioma.