Furthermore, XIST was shown to be upregulated in NSCLC tissues and cell lines and act as an oncogene by recruiting enhancer of zeste homolog 2 (EZH2), a member of the polycomb repressive complex 2 (PRC2), to the promoter of the tumor suppressor Krüppel-like factor 2 (KLF2) to initiate histone methylation to repress KLF2 expression [22]. Here, XIST is linked to non-small cell lung carcinoma.