Three lncRNAs upregulated in NSCLC, AFAP1 antisense gene 1 (AFAP1-AS1), small nucleolar RNA host gene 20 (SNHG20), and LINC01088, were shown to directly interact with EZH2, increasing binding and methylation of the p21 promoter and silencing of p21 expression [37,61,119]. This evidence concerns the gene EZH2 and non-small cell lung carcinoma.