Furthermore, focally amplified lncRNA on chromosome 1 (FAL1) lncRNA increased BMI1 polycomb ring finger oncogene (BMI1) levels, which downregulated phosphatase and tensin homolog (PTEN), an inhibitor of the PI3K/AKT pathway, increasing AKT activation and NSCLC tumorigenesis [42]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.