CD4 and plasma cell myeloma: For example, a review paper on pro-inflammatory and anti-inflammatory processes in patients with multiple myeloma, examined the effects of locally produced cytokines, as a primary immune response, and found that efficacious tumour immunosurveillance due to tumour-specific CD4+ T cells was consistently related to increased local concentrations of both proinflammatory (IL-6, IL-1α, and IL-1β) and Th1-associated cytokines (IL-2, IL-12, and IFN-γ) [71].