Arnardottir et al. and Kim et al. reported an interaction effect between OSAS severity and BMI on both IL-6 and/or CRP levels and suggested that the degree of obesity altered the relationships between OSAS severity and IL-6 concentrations and/or between OSAS severity and CRP levels [30,31]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.