MLKL and amyotrophic lateral sclerosis: Figure 4d shows an example of an ALS tissue containing a CTXLP+ neuron with an accumulation of MLKL staining in the axon hillock (arrow), as well as a nearby degenerating cell (co-localized CTXLP+MLKL+ puncta, asterisk). Typical of necroptosis [72], extracellular CTXLP deposits were also observed surrounding degenerating pyramidal neurons in the motor cortex of ALS patients (Figure 4d and Figure S7b).