Compared with the CTRL group, septic shock patients showed a significant increase in ND1 mtDNA plasma levels, expressed as copies/μL, at onset and over three following days (Figure 1; CTRL: 1208 (668–2685); septic shock onset: 3865 (2092–6332); septic shock 24 h: 3650 (1992–9129); septic shock 72 h: 3177 (2680–7318); CTRL vs. septic shock onset: p = 0.017; CTRL vs. septic shock 24 h: p = 0.013; CTRL vs. septic shock 72 h: p < 0.001; all other analyses regarding the analyzed timepoints resulted in p-values > 0.05). This evidence concerns the gene MT-ND1 and septic shock.