HO-1 is involved in the maintenance of cellular homeostasis and adaptation to cellular stress, as well as being implicated in cancer development, aggressiveness, and poor outcomes in gallbladder cancers, non-small cell lung cancer, cervical cancer, hepatoma, esophageal squamous cell carcinoma, and multiple myeloma [17,23,24,25]. This evidence concerns the gene HMOX1 and non-small cell lung carcinoma.