In addition, it has been shown to recruit Rho GTPases, cofilin and other motility associated effector proteins [38,39,45,78,79] This role of Annexin A2 in promoting breast cancer cell migration equates with results from previous research [44,80,81] but to our knowledge is the first instance to show the specific reaction to an EGF gradient. This evidence concerns the gene ANXA2 and breast carcinoma.