Apart from Annexin A2, calcium binding proteins such as the S100 family (several of which were identified in our screen, Table S1) have been thoroughly investigated in the context of cancer, as reviewed by Bresnick et al. [68] and these, along with Annexin A2, have the potential to be utilized as prognostic or therapeutic targets in breast cancer [69]. The gene discussed is ANXA2; the disease is cancer.