Additionally, while HAT applies well to multiple sclerosis antigens hidden within myelin and cardiac myosin in autoimmune myocarditis, it does not appear to be relevant to understanding autoimmunity targeted at acetylcholine in myasthenia gravis, insulin in type 1 diabetes, autoimmune thyroiditis or other AD that involve readily accessible extracellular autoantigens. Here, INS is linked to type 1 diabetes mellitus.