TLR2 and Sjogren syndrome: For example, TLR2, TLR3, TLR4 and NOD1 are activated in in both human patients and in animal models of Sjogren’s syndrome and autoimmune disease against cells producing tears, saliva and mucus [148,149] TLR7 and TLR9 are also implicated in the animal model though less certainly in human patients.