For example, TLR2 and 4 synergize in rheumatoid arthritis-derived synoviocytes [119,120], rheumatoid arthritis [120], sarcoidosis [121], systemic lupus erythematosus, systemic sclerosis, Sjogren’s syndrome, psoriasis, multiple sclerosis and autoimmune diabetes [120]. This evidence concerns the gene TLR2 and systemic lupus erythematosus.