Despite the wide range of adjuvants used in creating models of MS, CFA (TLR2, 4, 9 and NOD1, 2) could not be substituted by poly I:C (a TLR3 agonist) or zymosan (a TLR2 agonist) in the MOG-CFA model of EAE [61]. Here, TLR2 is linked to myeloid sarcoma.