This prediction more precisely states that one cannot, for example, replace the “adjuvant” in an animal model of an AD that stimulates TLR4 with one that stimulates TLR3 or TLR6, nor can one do away with the TLR/NOD activation by replacing it with a TLR- or NOD-independent adjuvant such as alum or incomplete Freund’s adjuvant. This evidence concerns the gene TLR4 and Alzheimer disease.