The top 20 immune-related pathways (Figure 6D) included Cell adhesion molecules (CAMs), Phagosome, Antigen processing and presentation, Hematopoietic cell lineage, Cytokine-cytokine receptor interaction, Allograft rejection, Intestinal immune network for IgA production, Th1 and Th2 cell differentiation, NF-kappa B signaling pathway, Complement and coagulation cascades, PI3K-Akt signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, primary immunodeficiency, Chemokine signaling pathway, and others. The gene discussed is AKT1; the disease is inborn error of immunity.