Collectively, our RNA-Seq analysis indicated that, compared to that in normal bronchial epithelial cells, hsa_circ_0000190 and hsa_circ_0001649 were highly upregulated in the lung cancer cell line A549 with wild-type EGFR expression, and were expressed at even higher levels in the lung cancer cells with constitutively active mutant EGFR. The gene discussed is EGFR; the disease is lung carcinoma.