In addition, DIM treatment decreased MDM2 in other cancer cell lines including A549 (p53 wild-type), NCI-H358 (p53 null), MCF-7 (p53 wild-type), and MIAPaCa-2 (p53 mutant) cells (Figure S1C), suggesting a common mechanism of action in various types of cancers. The gene discussed is TP53; the disease is cancer.