Thus, oligomeric α-synuclein interacts with the Hsp70 system that inhibits the chaperone activity by weak interactions with J-domain co-chaperones that may contribute to the disruption of protein homeostasis, impair organellar function, and contribute to the mechanism of neurodegeneration in Parkinson’s disease [39], but on the other hand, it can be a part of a natural neuronal control strategy to suppress α-synuclein aggregation [40]. The gene discussed is SNCA; the disease is Parkinson disease.