IDH2 and acute myeloid leukemia: Acquired somatic mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2), have been reported in acute myeloid leukemia (AML) [1], myelodysplastic syndromes (MDS), and chronic myeloproliferative neoplasms (MPN) [2,3].