ESR1 and breast carcinoma: Figure 4B shows the distribution of these immune cells between GR-high and GR-low groups in ER-positive/HER2-negative breast cancer and TNBC subtypes. We observed similar findings with the lower number of T-follicular helper cells (p < 0.01) in the GR-high group in both METABRIC and TCGA in the two subtypes. In ER-positive/HER2-negative subtype, lower T-regs were observed in GR-high breast cancer (p < 0.001); this finding was validated in TNBC in METABRIC, but not in TCGA.