Hypoxia and the glycolytic metabolism were also associated with a wide range of epigenetic alterations both in tumor and immune cells within the tumor microenvironment, as shown in different cancer models, and HIF-2α (hypoxia-inducible factor 2 alpha) interaction with beta-catenin was recently shown in pancreatic cancer [71,72]. This evidence concerns the gene EPAS1 and familial pancreatic carcinoma.