Chemotherapy drugs approved for pancreatic cancer treatment, such as Fluorouracil (5-FU) and platins, have been tested in combination with ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1) silencing and T-type Ca2+ channels blockers in hepatocellular carcinoma and ovarian cancer, respectively, with promising effects [80,81]. This evidence concerns the gene ORAI1 and pancreatic neoplasm.