BGLAP and SAPHO syndrome: A retrospective analysis showed that the main mechanism of bone destruction in SAPHO syndrome was the enhancement of bone resorption, and the level of β-CTX could reflect the disease activity of SAPHO syndrome.[19] After the 1.5 mg/(kg·d) Tripterygium glycosides treatment, the increase of serum osteocalcin accompanied by the decrease of serum β-CTX, suggested that Tripterygium glycosides may also have a pharmacological effect of inhibiting osteolysis and enhancing bone strength, which is consistent with the study of Huang et al.[20]