ALK and non-small cell lung carcinoma: In a randomized, open-label, phase 3 trial, Peters et al assigned 303 patients with previously untreated, advanced ALK-positive NSCLC to receive either oral Alectinib at a dose of 600 mg twice daily (to be taken with food) or oral Crizotinib at a dose of 250 mg twice daily (to be taken with or without food).