Our knowledge of the abundance of trace elements in human tissues and fluids has increased significantly due to improvements in the analytical methods, which have become a useful approach in exploring the relationship between basic composition of body fluids and tissues, pathological conditions, and general nutritional status.[8–10] However, evidence on essential element status and its relation to IGF-1 and IGF-2 among individuals at risk for osteoporosis, such as postmenopausal women, is scarce. The gene discussed is IGF1; the disease is osteoporosis.