In the following years, the patient gradually presented with other several characteristics of POEMS syndrome, including M-proteinemia, sclerotic bone lesions, increased serum VEGF levels, splenomegaly, amenorrhea with hypothalamic gonadal hypofunction, skin changes, and bilateral papilledema, but who remained free of any symptoms of polyneuropathy 5 years after the onset of skin change. This evidence concerns the gene VEGFA and optic papillitis.