A modern medical research has found that 5-HMF, the main active component of Alpinia oxyphylla Miq, can improve the memory impairment of mice induced by Aβ1–42, which has a potential therapeutic effect on dementia.[14]Lycii Fructus extract can improve the cognitive function in mice of Alzheimer's disease, reduce Aβ deposition, and regulate the expression of brain neurotrophic derived factor and tyrosine kinase B. [15]. Here, BDNF is linked to Alzheimer disease.