However, the description about diagnostic criteria and treatment plan has increased the awareness and early recognition of the disease in recent years.[33] Hence, there is no clarity in explanation of mucin deposition origin, paraprotein role and factors primarily implicated in the disease progression.[34] Although, few cases of scleromyxedema were reported to be associated with neoplasms[35] and bone marrow malignancies such as multiple myeloma,[36] lymphoma,[37] and myelomonocytic leukemia.[38]. The gene discussed is MUC5AC; the disease is plasma cell myeloma.