This specific case had the following characteristics: adequate glycemic control (HbA1c ≤8.0% [64 mmol/mol]); 61 years old; man; high school education level; 17 years of T2DM since the diagnosis; OAD associated with insulin treatment; 3 antidiabetic medicines; BMI of 36.5 kg/m2; LDL-cholesterol of 117 mg/dl; triglyceride level of 1473.5 mg/dl; SBP of 145 mmHg; and 2 diabetes consultations in the last twelve months. The gene discussed is INS; the disease is type 2 diabetes mellitus.