CASP3 and triple-A syndrome: Furthermore, RT-qPCR and Western blot analysis revealed that compared with the AAA mice injected with LV-NC, AAA mice injected with LV-Sox2ot and LV-Egr1 both exhibited increased levels of M-CSF, MCP-1, MIP-2, ICAM-1, cleaved caspase-3, NOX4, iNOS, and p47phox whereas decreased levels of collagen I and collagen III, which verified that upregulation of lncRNA Sox2ot and Egr1 could stimulate inflammation and oxidative stress in AAA mice.