In genome wide association studies (GWAS) of cardiovascular patients, the SH2B3 phosphorylation related missense variant rs3184504 was found to be associated with increased platelet count, monocyte proliferation, hypertension, peripheral/coronary artery disease, autoimmune disease, and longevity [9], [10], [11], [12], [13], [14], [15]. This evidence concerns the gene SH2B3 and coronary artery disorder.