Pro‐inflammatory mediators such as TNF‐α, but also hyperammonemia, activate nuclear factor ‘kappa‐light‐chain‐enhancer’ of activated B cells (NF‐κB) signalling and induce, in part mediated by myostatin, downstream target genes including MuRF‐1 and atrogin‐1 (MAFbx) that promote muscle protein degradation through the proteasomal pathway.53, 54. Here, NFKB1 is linked to Hyperammonemia.