Three proteins were implicated in the pathogenesis of schizophrenia: (i) Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1; SIRPA)–Fig 3, (ii) Tumor necrosis factor receptor superfamily member 5 (CD40), and (iii) Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B). The gene discussed is SIRPA; the disease is schizophrenia.