We note previous support for these inferences: for example, tocilizumab (a humanized monoclonal antibody against IL6R protein) is in clinical use for treating rheumatoid arthritis [53], prior MR evidence has linked elevated levels of soluble IL6R to reduced cardiovascular disease [54,55], and, as discussed above, there is previous genetic evidence of a link between IL6R and atopy [41,48–52]. Here, IL6R is linked to rheumatoid arthritis.