In a genome-wide association study of more than 2400 cases of aortic valve stenosis (a pathology that hits about 5% of MOWS patients), this region harbors single-nucleotide polymorphisms in the non-coding RNA TEX41, located about 150 kb upstream of the ZEB2 TSS, that directly interact with LINC01412 and the ZEB2 proximal promoter region (21,34). Here, ZEB2 is linked to stricture.