In a genome-wide association study of more than 2400 cases of aortic valve stenosis (a pathology that hits about 5% of MOWS patients), this region harbors single-nucleotide polymorphisms in the non-coding RNA TEX41, located about 150 kb upstream of the ZEB2 TSS, that directly interact with LINC01412 and the ZEB2 proximal promoter region (21,34). This evidence concerns the gene ZEB2 and aortic valve stenosis.