A significant Bcl-2 down expression and a consequent increase in the Bax/Bcl-2 ratio in LAIR-1 overexpression tumor samples suggests that apoptosis via the regulation of the PI3K-AKT pathway and Bcl-2 family proteins may play an important role in the tumor suppressive function of LAIR-1 in vivo. The gene discussed is BCL2; the disease is neoplasm.