PTEN and triple-negative breast carcinoma: Nonetheless, our findings are consistent with previous studies demonstrating that loss of PTEN and activation of AKT leads to reduced nuclear localization and impaired CHK1 function (Puc et al., 2005) and lethal interactions between inhibition of CHK1 and WEE1 in triple-negative breast cancers (TNBCs) (Aarts et al., 2012).