Since endogenous tPA has also been demonstrated to induce BBB damage after peripheral thermal injury36 and traumatic brain injury37 and neuroserpin has been shown to reduce cerebral infarct volume, protect neurons from ischaemia‐induced apoptosis,24 and increase the therapeutic window for tissue‐type plasminogen activator administration in a rat model of embolic stroke,38 endogenous tPA could be a promising target to reduce BBB damage after various stress. The gene discussed is PLAT; the disease is stroke disorder.