Among the 177 ASEs, 18 ASEs were significantly connected with bone metastasis, especially, ABCA6-43162-AT and PLIN5-46808-AT, which were both associated with OS (P=0.041, P=0.048), bone metastasis (P=0.032, P=0.019) and co-expressed with YBX3 (correlation coefficient = 0.410, P<0.001; correlation coefficient = −0.416, P<0.001) (Figure 6B–H). The gene discussed is ABCA6; the disease is bone metastasis.