IL1B and acute respiratory distress syndrome: However, another study showed that pre‐treatment with alpha‐mangostin partly inhibited the activation of autophagic cell death via down‐regulation of p‐mTOR, p‐AKT and the LC3II/LC3I ratio, subsequently decreasing the release of inflammatory factors, including tumour necrosis factor (TNF)‐α and IL‐1β, and inhibiting the activation of apoptotic pathways in APAP‐induced ALI models.39