CISH and Hypertension: 2020). In vascular smooth muscle cells (VSMCs), SOCs are stimulated by vasoconstrictors that activate the Gαq protein‐coupled receptor signalling pathway leading to phospholipase C (PLC) activity, phosphatidylinositol 4,5‐bisphosphate (PIP2) hydrolysis, inositol 1,4,5‐trisphosphate (IP3) generation and IP3‐mediated depletion of SR Ca2+ stores. As such SOCs induce Ca2+ entry pathways that regulate vasoconstrictor‐mediated contraction, proliferation and migration, and are considered drug targets for treatment of vascular diseases such as hypertension and atherosclerosis.