The present study aimed to investigate the role of sirtuin 1 (SIRT1)- and transcription box-3 (TBX-3)-mediated regulation of endothelial dysfunction, given the significance of SIRT1 in glucose metabolism and the role of TBX-3 in the maintenance of cellular proliferation, senescence and apoptosis. This evidence concerns the gene SIRT1 and endothelial dysfunction.