Among the 85 SLE patients, 40 (47.1%) patients were positive for anti-Sm antibody, 55 (64.7%) were positive for anti-dsDNA antibody, 45 (52.9%) were positive for anti-SSA/Ro 52 kD antibody, 56 (65.9%) were positive for anti-SSA/Ro 60 kD antibody, 30 (35.3%) were positive for anti-SSB/La antibody, and 10 (11.8%) were positive for aCL antibody. The gene discussed is CALR; the disease is systemic lupus erythematosus.