Therefore, the genetic effects of heterozygous of ICAM1 E469K and its related functional changes that we have been reported in the present study may not be the findings “by chance.” Liu et al. have conducted a meta-analysis for ICAM1 E469K polymorphism and DKD in several cohorts by using allelic, dominant, recessive, and additive models. Here, ICAM1 is linked to diabetic kidney disease.