A case-control study in the USA with >3000 White, Hispanic, African-American, and Asian cases and controls examined the haplotypes of three SNPs spanning across the VDR gene, including BsmI (intron 8), poly(A) long (18-22 repeats), and FokI (exon 2), and reported an association of the bLF and BLF haplotypes with the risk of colon cancer [27]. Here, VDR is linked to malignant colon neoplasm.