HBV is the smallest enveloped dsDNA animal that belongs to the Hepadnaviridae family, and its DNA genome is an incomplete double strand of 3.2 kb [4] organized into four open reading frames that overlap and code for HBc capsid, HB surface protein (envelope), reverse transcriptase, and nonstructural protein X (HBx) [5], which is known for its oncogenic properties and believed to induce hepatocellular carcinoma (HCC). Here, KRT88P is linked to hepatocellular carcinoma.