In the ICGC cohort, univariate Cox suggested that higher C2 expression was significantly related with better OS (HR = 0.46, 95% CI: 0.25-0.86, p = 0.02, Figure 3(c)), and multivariate analysis also showed that C2 expression was independently associated with OS of HCC patients after adjusting for gender, age, and TNM stage (HR = 0.73, 95% CI: 0.27-0.96, p = 0.04, Table 4). Here, C2 is linked to hepatocellular carcinoma.