CASP1 and Sepsis: Dai et al. established a classic septic model in rats by CLP and attenuated sepsis-induced renal injury by inhibiting NLRP3 and caspase-1 [24]; Liu et al. also found that TQ attenuated sepsis-induced cardiac injury by reducing the expression of NLRP3 and caspase-1 [25]; these results are in agreement with our research.